Detect differentially methylated regions using non-homogeneous hidden Markov model for methylation array data
نویسندگان
چکیده
منابع مشابه
Detect differentially methylated regions using non-homogeneous hidden Markov model for methylation array data
Motivation DNA methylation is an important epigenetic mechanism in gene regulation and the detection of differentially methylated regions (DMRs) is enthralling for many disease studies. There are several aspects that we can improve over existing DMR detection methods: (i) methylation statuses of nearby CpG sites are highly correlated, but this fact has seldom been modelled rigorously due to the...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2017
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btx467